Shrien Dewani, who has been suffering from clinical depression and a stress disorder, was taken to Bristol Royal Infirmary on Sunday, Max Clifford said.
South African authorities want him to be extradited to stand trial accused of ordering the shooting of his wife Anni.
Mr Dewani has denied any involvement in his wife's death.
The 31-year-old, who is on bail, was unable to attend a recent court hearing because he is suffering from depression and severe post-traumatic stress disorder.'Increasingly concerned'
Mr Clifford said: "He's been increasingly ill over the last couple of months, he's been losing weight.
"Those close to him obviously have become increasingly concerned about his health.
"All Shrien wants, all the family wants, is for the truth to come out.
"If the truth comes out it will be clearly shown that he had nothing to do with this tragedy.
"When he comes out of hospital he is probably going to have to have 24-hour nursing."
Mr Dewani and his 28-year-old Swedish wife had been married for two weeks when she was killed.
The couple's taxi was hijacked on 13 November in Cape Town as they travelled through the Gugulethu township.
Mrs Dewani's body was later found in the abandoned car. Mr Dewani had been released unharmed.
One of the men accused of murdering Mrs Dewani, Mziwamadoda Qwabe, has claimed in a statement released by police that the hijacking which led to her death was staged.
Mr Qwabe and Xolile Mngeni are charged with murder, kidnapping and robbery with aggravating circumstances.
They are due to appear before Wynberg Regional Court in Cape Town on 25 February.
Taxi driver Zola Tongo has already been jailed for 18 years after admitting his role in the murder and making a confession that implicated Mr Dewani.
An extradition hearing has been set for 3 May at Woolwich Crown Court.
Lawyers for Mr Dewani have said they will question whether he would receive a fair trial if extradited.
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