Deputy Liberal Democrat leader Simon Hughes will join campaigners in mid Wales, whilst Plaid Cymru launch a last-push advertising campaign.
Labour's Carwyn Jones will make his last speech of the campaign at the marginal seat of Aberconwy.
Welsh Conservative leader Nick Bourne is to be joined by Welsh Secretary Cheryl Gillan.
Welsh Lib Dem leader Kirsty Williams is to resume her attack on Labour and Plaid, accusing them of avoiding responsibility for "the failures" of the last assembly government.
"Labour's Mr Jones blames Westminster," she said. "Plaid Cymru's Mr Jones blames Labour's Mr Jones."
"Labour and Plaid, together in government, have left us with a weak economy, under-funded schools and an NHS that costs more but delivers less."
Ms Williams said Wales needed a government that would "get on with the job" of improving things not just blaming everyone else.
Meanwhile, Carwyn Jones has chosen Aberconwy, a three-way marginal, to make his last speech of the campaign.
The Welsh Labour leader will say that his party can provide an alternative to Westminster government cuts which are "too far and too fast".Health and employment
Claiming that the Con-Lib coalition plans were "hurting but not working", Mr Jones will say that with a Labour government "Wales can show the way" in keeping fairness at the heart of government.
Plaid Cymru will be launching their final advertising push with leader Ieuan Wyn Jones stating Wales needed "innovative ways to defy the [public spending] crisis".
Criticising other parties as "uninspiring and devoid of real ideas", he will warn that "Labour cannot be allowed to take the support of the people of Wales for granted".
Emphasising his party's plans to improve employment, education and skills, Mr Jones asked people to vote for Plaid's "fresh ideas and new ways of working" that "offer a beacon of hope that Wales can rise to the challenges we face".
The Conservatives will focus on health, and Mr Bourne said: "In the final hours of the campaign we will be promoting our commitment to reverse Labour's £1bn cuts to the Welsh NHS.
"Welsh Conservatives are the only party committed to protecting the NHS budget and increasing it in line with inflation.
"Protecting the NHS budget will allow us to invest in a £10million cancer drugs fund, to improve ambulance response times and address the under funding of Welsh hospices."
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